Dietary bioflavonoids induce apoptosis in human leukemia cells.
نویسندگان
چکیده
Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
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عنوان ژورنال:
- Leukemia research
دوره 29 5 شماره
صفحات -
تاریخ انتشار 2005